Lo
| Model name: | Lo2016 |
| Overall impression of the model: | nearly curated and partly annotated |
| Curators: | Soria Gasparini Atreyee Banerjee Bastien Chassagnol |
| Biological context: | Inflammatory Bowel Disease: How Effective Is TNF-α Suppression? |
| Paper: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0165782 |
| Does the model reproduce a figure? (Figure number) | Table 4, steady state values are in the order of magnitude, but not match exactly |
| All equations translated to SBML? | Yes |
| Is model annotated? | macrophages annotated; cytokines and T cells missing |
| What was the source of the model? (equations in the paper or file) | Equations were translated and small errors fixed (see readme) |
Notes:
- A complex model and paper figures are not straightforward to reproduce
- Steady state values reproduced within order of magnitude
- Curator's note on the reproducibility of this model: "Fig2: Sensitivity analyses: without the code and the random seed, may exhibit sensitive discrepancies Fig3: Dysregulated mechanisms: infer back the variations of the parameters would require that the omics expression profiles are left available, which is not the case"
- Curators wish to work further on this model