Hayashi

Model name:	Hayashi2013
Overall impression of the model:	two models curated and annotated Reproduced model A and model B in Copasi and Tellurium. Typo in the figure legend in ipynb files.
Curators:	Ali Mushtaq Francisco Arriaza Gallardo Alina Jansen
Biological context:	Suppressing TNF-induced proinflammatory gene expressions in murine fibroblasts and 3T3 cells
Paper:	https://biosignaling.biomedcentral.com/articles/10.1186/1478-811X-11-84
Does the model reproduce a figure? (Figure number)	Fig 2B., ipynb reproduces results; the SBML file had to be modified by setting mutant parameters to 0 manually and exported graphs to compare results
All equations translated to SBML?	na
Is model annotated?	yes
What was the source of the model? (equations in the paper or file)	SBML files

Notes:
To reproduce results of the figure 2B the following parameters were set to 0:

Model A (linear response model):

mutants = {'traf2':['cIAP1_2____TRAF2_k1'],
            'traf5': ['cIAP1_2____TRAF5_k1'],
            'traf2_5': ['cIAP1_2____TRAF2_k1', 'cIAP1_2____TRAF5_k1'],
            'traf6': ['TRADD____TRAF6_k1'],
            'rip1': ['TRAF2____RIP1_k1', 'TRAF5____RIP1_k1', 'TRAF6____RIP1_k1'],
            'tradd': ['TNFR1____TRADD_k1']
             }

Model B (higher order terms and MM type kinetics):

mutants = {'traf2':['reaction_48'],
            'traf5': ['reaction_4'],
            'traf2_5': ['reaction_48', 'reaction_4'],
            'traf6': ['reaction_3'],
            'rip1': ['reaction_5', 'reaction_6', 'reaction_7'],
            'tradd': ['reaction_1']
             }

- the models can be submitted to BioModels